Season 5 Zyra Support (5.9) - Carry from the bot lane - By Melyn - League of Legends Guides - LoLPro
I usually go with the above runes, though I may switch out the MR glyphs for ability power. Really, it depends on the lane. Recently, I have been using AP glyphs whenever there isn't an AP support on the enemy team. You may still wish to choose the safer ...