Vitamin[thinsp]C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells : N
a, Dose-dependent effect of vitamin C on in vitro Tet activity (n = 3 technical replicates, values are mean ± s.d.). b, Dot blot analysis for 5hmC after 12 h vitamin C treatment. DKO, double knockout; WT, wild-type. c, 5hmC (top) and 5mC (bottom) DIP-qPCR...