Role of Tet proteins in 5mC to 5hmC conversion, ES cell self-renewal, and ICM specification
To determine whether Tet1 knockdown causes spontaneous differentiation, we stained the cells with the mouse ES cell surface marker SSEA-1 and found that Tet1 knockdown resulted in 10–15% increase in SSEA-1 negative cells (Fig. S9a). RT-qPCR analysis of .....