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Role of Tet proteins in 5mC to 5hmC conversion, ES cell self-renewal, and ICM specification

To determine whether Tet1 knockdown causes spontaneous differentiation, we stained the cells with the mouse ES cell surface marker SSEA-1 and found that Tet1 knockdown resulted in 10–15% increase in SSEA-1 negative cells (Fig. S9a). RT-qPCR analysis of .....

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