Selective hydrolysis of methyl ester in presence of t- butyl ester
I cleave Me esters frequently without bothering tBu esters. Use 1M LiOH (1-4 eq) in 1,4-dioxanes overnight at RT. It should not touch the tBu ester. Raising the temp much or leaving the reaction in strong acid for any time are both bad for tBu esters. For...