Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations : Nature :
Phosphofructokinase-1 (PFK1), the /`gatekeeper/' of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over ten metabolites an...